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Home About Traditions &＃038; History Careers at YCU Academics Undergraduate Study School of International Liberal Arts School of Economics and Business Administration School of Science School of Data Science School of Medicine School of Medicine: Medical Course School of Medicine: Nursing Course Graduate Study Graduate School of Urban Social and Cultural Studies Graduate School of International Management Graduate School of Nanobioscience Graduate School of Nanobioscience: Department of Materials System Science Graduate School of Nanobioscience: Department of Life and Environmental System Science Graduate School of Data Science Graduate School of Data Science: Department of Data Science Graduate School of Data Science: Department of Health Data Science Graduate School of Medical Life Science Graduate School of Medicine Graduate School of Medicine: Department of Medicine Graduate School of Medicine: Department of Nursing Non-Degree Programs Exchange Program International Clinical Clerkship Research-Only Career Development Support Admissions Research Advanced Medical Research Center Kihara Institute for Biological Research Life at YCU Kanazawa-Hakkei Campus Life Fukuura Campus Life Living in Yokohama Clubs &＃038; Societies Health &＃038; Wellness Global International Affairs Office Exchange Program Partner Institutions Global Cooperation Institute for Sustainable Cities (GCI) 日本語 Simplifying the Estimation of Volatile Organic Compounds Emitted From Wildfires2023-10-26Changes in the Number of Gastrointestinal Cancers and Stage at Diagnosis with COVID-19 Pandemic in Japan: A Multicenter Cohort Study Cancers2023-11-06 Show all Structural bases for the Charcot-Marie-Tooth disease induced by single amino acid substitutions of myelin protein zero Date: 2 Nov 23 Researcher(s): Masayoshi Sakakura,Hideo Takahashi Myelin protein zero (MPZ or P0) is a transmembrane protein which functions to glue membranes in peripheral myelin. Inter-membrane adhesion is mediated by homophilic interactions between the extracellular domains (ECDs) of MPZ. Single amino acid substitutions in an ECD cause demyelinating neuropathy, Charcot-Marie-Tooth disease (CMT), with unknown mechanisms. In this study, by using a novel assay system “nanomyelin,” we revealed that a stacked-rings-like ECD-8-mer is responsible for membrane adhesion. Two inter-ECD interactions, cis and head-to-head, are essential to constituting the 8-mer and to gluing the membranes. This result was reinforced by the observation that the CMT-related N87H substitution at the cis interface abolished membrane-adhesion activity. In contrast, the CMT-related D32G and E68V variants retained membrane-stacking activity, whereas their thermal stability was lower than that of the WT. Reduced thermal stability may lead to impairment of the long-term stability of ECD and the layered membranes of myelin. Link to full article For inquiries regarding this press release Masayoshi SakakuraAssociate Professor Graduate School of Medical Life Science, Yokohama City University, Yokohama 230-0045, Japan Hideo TakahashiProfessor Graduate School of Medical Life Science, Yokohama City University, Yokohama 230-0045, Japan Search ✕ Latest newsActivity of MEXT Scholarship Alumni After Returning to Their Home Country2024-04-25Intraoperative Integrated Diagnostic System for Malignant Central Nervous System Tumors2023-11-21 Research Research News Advanced Medical Research Center Kihara Institute for Biological Research Researcher Database Global International Affairs Office International Student Support Exchange Program Partner Institutions Global Cooperation Institute for Sustainable Cities (GCI) GCI: Overview GCI: Activities International Academic Consortium for Sustainable Cities (IACSC) Living in Yokohama Admissions 22-2 Seto, Kanazawa-ku, Yokohama, Kanagawa 236-0027 Japan Undergraduate Schools International Liberal Arts Economics and Business Administration Science Data Science Medicine Graduate Schools Urban Social and Cultural Studies International Management Nanobioscience Medical Life Science Medicine  Data Science Admissions Undergraduate Graduate Non-Degree Programs Research Advanced Medical Research Center Kihara Institute for Biological Research Research Database Hospitals Yokohama City University Hospital Yokohama City University Medical Center Life at YCU Campus Life Living in Yokohama Clubs & Societies Health & Wellness Global International Affairs Office Global Cooperation Institute for Sustainable Cities Exchange Programs Partner Institutions NewsActivity of MEXT Scholarship Alumni After Returning to Their Home Country2024-04-25Simplifying the Estimation of Volatile Organic Compounds Emitted From Wildfires2023-10-26Event Report: The 14th IACSC International Symposium/General Assembly2023-10-10 © 2021 Yokohama City University. 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