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Home About Traditions &＃038; History Careers at YCU Academics Undergraduate Study School of International Liberal Arts School of Economics and Business Administration School of Science School of Data Science School of Medicine School of Medicine: Medical Course School of Medicine: Nursing Course Graduate Study Graduate School of Urban Social and Cultural Studies Graduate School of International Management Graduate School of Nanobioscience Graduate School of Nanobioscience: Department of Materials System Science Graduate School of Nanobioscience: Department of Life and Environmental System Science Graduate School of Data Science Graduate School of Data Science: Department of Data Science Graduate School of Data Science: Department of Health Data Science Graduate School of Medical Life Science Graduate School of Medicine Graduate School of Medicine: Department of Medicine Graduate School of Medicine: Department of Nursing Non-Degree Programs Exchange Program International Clinical Clerkship Research-Only Career Development Support Admissions Research Advanced Medical Research Center Kihara Institute for Biological Research Life at YCU Kanazawa-Hakkei Campus Life Fukuura Campus Life Living in Yokohama Clubs &＃038; Societies Health &＃038; Wellness Global International Affairs Office Exchange Program Partner Institutions Global Cooperation Institute for Sustainable Cities (GCI) 日本語 Loss of Pancreatic E-Cadherin Causes Pancreatitis-Like Changes and Contributes to Carcinogenesis2019-11-26Women in Data Science (WiDS) Tokyo @ Yokohama City University2020-01-10 Show all A GM1b/asialo‐GM1 oligosaccharide‐binding R‐type lectin from purplish bifurcate mussels Mytilisepta virgata and its effect on MAP kinases Date: 3 December 2019 A 15‐kDa lectin, termed SeviL, was isolated from Mytilisepta virgata (purplish bifurcate mussel). SeviL forms a noncovalent dimer that binds strongly to ganglio‐series GM1b oligosaccharide (Neu5Acɑ2‐3Galβ1‐3GalNAcβ1‐4Galβ1‐4Glc) and its precursor, asialo‐GM1 (Galβ1‐3GalNAcβ1‐4Galβ1‐4Glc). SeviL also interacts weakly with the glycan moiety of SSEA‐4 hexaose (Neu5Acα2‐3Galβ1‐3GalNAcβ1‐3Galα1‐4Galβ1‐4Glc). A partial protein sequence of the lectin was determined by mass spectrometry, and the complete sequence was identified from transcriptomic analysis. SeviL, consisting of 129 amino acids, was classified as an R(icin B)‐type lectin, based on the presence of the QxW motif characteristic of this fold. SeviL mRNA is highly expressed in gills and, in particular, mantle rim tissues. Orthologues sequences were identified in other species of the family Mytilidae, including Mytilus galloprovincialis, from which lectin MytiLec‐1 was isolated and characterized in our previous studies. Thus, mytilid species contain lectins belonging to at least two distinct families (R‐type lectins and mytilectins) that have a common β‐trefoil fold structure but differing glycan‐binding specificities. SeviL displayed notable cytotoxic (apoptotic) effects against various cultured cell lines (human breast, ovarian, and colonic cancer; dog kidney) that possess asialo‐GM1 oligosaccharide at the cell surface. This cytotoxic effect was inhibited by the presence of anti‐asialo‐GM1 oligosaccharide antibodies. With HeLa ovarian cancer cells, SeviL showed dose‐ and time‐dependent activation of kinase MKK3/6, p38 MAPK, and caspase‐3/9. The transduction pathways activated by SeviL via the glycosphingolipid oligosaccharide were triggered apoptosis.Link to full article   For inquiries regarding this press release Yasuhiro OZEKIProfessor, Yokohama City University School of [email protected] Search ✕ Latest newsActivity of MEXT Scholarship Alumni After Returning to Their Home Country2024-04-25Intraoperative Integrated Diagnostic System for Malignant Central Nervous System Tumors2023-11-21 Research Research News Advanced Medical Research Center Kihara Institute for Biological Research Researcher Database Global International Affairs Office International Student Support Exchange Program Partner Institutions Global Cooperation Institute for Sustainable Cities (GCI) GCI: Overview GCI: Activities International Academic Consortium for Sustainable Cities (IACSC) Living in Yokohama Admissions 22-2 Seto, Kanazawa-ku, Yokohama, Kanagawa 236-0027 Japan Undergraduate Schools International Liberal Arts Economics and Business Administration Science Data Science Medicine Graduate Schools Urban Social and Cultural Studies International Management Nanobioscience Medical Life Science Medicine  Data Science Admissions Undergraduate Graduate Non-Degree Programs Research Advanced Medical Research Center Kihara Institute for Biological Research Research Database Hospitals Yokohama City University Hospital Yokohama City University Medical Center Life at YCU Campus Life Living in Yokohama Clubs & Societies Health & Wellness Global International Affairs Office Global Cooperation Institute for Sustainable Cities Exchange Programs Partner Institutions NewsActivity of MEXT Scholarship Alumni After Returning to Their Home Country2024-04-25Simplifying the Estimation of Volatile Organic Compounds Emitted From Wildfires2023-10-26Event Report: The 14th IACSC International Symposium/General Assembly2023-10-10 © 2021 Yokohama City University. 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