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  大学ホームページ 図書館ホームページ 運営規程 登録・公開許諾書 パンフレット  更新日：2024/05/22    件数：7,050件     TOP  Language   JapaneseEnglishヘルプ No.1(全1件)     検索画面戻る一覧 Preclinical Study of Tacrolimus Ointment for Prevention of Its Systemic Absorption in Atopic Dermatitis Model Mice According to Their Skin Conditionsこのページを印刷URL:   ダウンロード  IDJOS-jjphcs.43.477著者：名前間, 祐太朗/内田, 亘/前川, 俊久/三木, 涼太郎/大島, 新司/江川, 祐哉/細谷, 治/関, 俊暢著者：別形式Hazama, Yutaro / Uchida, Wataru / Maekawa, Toshihisa / Miki, Ryotaro / Oshima, Shinji / Egawa, Yuya / Hosoya, Osamu / Seki, Toshinobu著者：カナハザマ, ユウタロウ/ウチダ, ワタル/マエカワ, トシヒサ/ミキ, リョウタロウ/オオシマ, シンジ/エガワ, ユウヤ/ホソヤ, オサム/セキ, トシノブ著者：所属城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部著者：所属(別形式）Josai University, Faculty of Pharmaceutical Science / Josai University, Faculty of Pharmaceutical Science / Josai University, Faculty of Pharmaceutical Science / Josai University, Faculty of Pharmaceutical Science / Josai University, Faculty of Pharmaceutical Science / Josai University, Faculty of Pharmaceutical Science / Josai University, Faculty of Pharmaceutical Science / Josai University, Faculty of Pharmaceutical Science著者版フラグpublisher出版地東京出版者日本医療薬学会出版者：カナニホンイリョウヤクガクカイ出版者：別名Japanese Society of Pharmaceutical health Care and SciencesNCIDAA11527197冊子ISSN1346342X電子ISSN18821499掲載誌名医療薬学掲載誌名：翻訳Japanese Journal of Pharmaceutical Health Care and Sciences巻43号9刊行年月2017-09開始ページ477終了ページ491コンテンツ作成日2017-03-22コンテンツ修正日2017-07-25コンテンツ登録日2018-10-22識別番号：DOIinfo:doi/10.5649/jjphcs.43.477識別番号：DOI（リンク）https://doi.org/10.5649/jjphcs.43.477医中誌ID2018163200抄録Tacrolimus (TL) is used topically for atopic dermatitis (AD) treatment. In AD, the skin shows various physiological alterations across individuals, body sites, and time-courses. Our previous study using rats showed that alterations in the skin barrier function and skin blood flow affected systemic absorption of topically applied TL. In this study, we performed an in vivo skin absorption study using NC/Nga mice repeatedly administered Dermatophagoides farinae extract as an AD animal model to assess skin barrier function and skin blood flow. We used three types of TL ointment: or iginal TL ointment (Protopic® 0.1％ ointment) and liquid paraffin-diluted TL ointment with or without adrenaline (0.5w /w％) to suppress systemic absorption of TL. Skin barrier function correlated positively with the systemic absorption of TL in AD skin as well as in tape-stripped rat skin, and dilution of TL ointment suppressed TL absorption and showed high skin TL retention. Although skin blood flow affected TL absorption as the skin barrier was disrupted, the distinct relationship among skin blood flow, TL absorption, and the effect of combined-use of adrenaline was unclear. The relationship between blood and skin disposition of TL was biphasic—the ratio of blood to skin disposition increased rapidly at an inflection point. These results demonstrate that the dilution of TL ointment is useful for increasing treatment safety while retaining efficacy. The observed relationship between TL behavior and skin barrier function in AD model mice may also occur in AD patients and needs to be confirmed in further studies.キーワードtacrolimus/skin absorption/atopic dermatitis/transepidermal water loss/skin blood flow/NC/Nga mouse言語 eng資源タイプtextジャンル01学術雑誌論文 / Journal Articleフォーマットapplication/pdf権利Copyright © 2017 Japanese Society of Pharmaceutical Health Care and Sciencesこのアイテムを表示する：本文(pdf)( 792.7KB) ダウンロード回数： 回このアイテムを表示する：URIhttp://libir.josai.ac.jp/il/meta_pub/G0000284repository_JOS-jjphcs.43.477URL:G0000284repository_JOS-jjphcs.43.477  var xurl =document.URL; var xrecid = 'G0000284repository_JOS-jjphcs.43.477'; var xReg = new RegExp(/(.*meta.*\/)/); var xmatch = xurl.match(xReg); var urlstr = RegExp.$1; if( xmatch) jQuery('a#infolib_permalink').html( urlstr + xrecid ); detailcont["max"] = '0'; detailcont["detailViewFlg"] = '0'; var xswitchViewButton = jQuery('div#detailContentsSwicher'); xswitchViewButton.show(); var xEditorButton = jQuery('div#detailEditor'); if( xEditorButton.length) { xpanel.xEditorPrime = "JOS-jjphcs.43.477"; xEditorButton.show(); } detailcont["contentsDspMax"] = '5'; detailcont["show"] = 'all'; detailcont["contentsDbId"] = 'G0000284repository'; detailcont["currentContNo"] = '0'; meta.detailSetViewerHeight(); Copyright(C) 2010 Josai University. All Rights Reserved　　※Internet Explorer をお使いの方はVer.8以上をご利用願います。