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入学希望の方一般・社会人の方研究者の方同窓生の方在学生の方教職員の方 日本語 (Japanese) Graduate School of Life Sciences, Tohoku University Access sitemap Link Tohoku University HOMEAbout UsAbout UsMessage from the DeanOrganizationMovieResearchLaboratories Department of Integrative Life Sciences Department of Ecological Developmental Adaptability Life Sciences Department of Molecular and Chemical Life SciencesResearchAwardEducationDegree ProgramsCourseSyllabusScheduleStudent LifeAdmissionAdmission InformationApplicationExamination Schedule and Application GuidelinesInformation Session(2024)Admission and Tuition FeesAdmission PolicyVoices from Graduates and Current StudentsAdmissions Q&AInquiries about Entrance ExaminationsFinancial SupportFor StudentsGraduate School&＃039;s Message Board for Students Information about Completion and Advancement to the Doctoral Course ProceduresCertificatesAbout Issuance of Various CertificatesNotice Regarding the Suspension of Operation of the Automatic Certificate Issuing MachinesLeave of absence/withdrawal from universityCampus Life, Various consultation servicesContactAccessLinkSitemapInformationAdmissionResearchAwardSeminarJobNewsAnnouncementOther MENU HOMEAbout UsAbout UsMessage from the DeanOrganizationMovieResearchLaboratoriesResearchAwardEducationDegree ProgramsCourseSyllabusScheduleStudent LifeAdmissionAdmission InformationApplicationExamination Schedule and Application GuidelinesInformation Session(2024)Admission and Tuition FeesAdmission PolicyVoices from Graduates and Current StudentsAdmissions Q&AInquiries about Entrance ExaminationsFinancial SupportFor StudentsGraduate School&＃039;s Message Board for Students Information about Completion and Advancement to the Doctoral Course ProceduresCertificatesLeave of absence/withdrawal from universityCampus Life, Various consultation servicesContactAccessLinkSitemapInformationAdmissionResearchAwardSeminarJobNewsAnnouncementOther 日本語 (Japanese) CLOSE Graduate School of Life Sciences, Tohoku University. Field Integrative Life Sciences :Developmental Regulation Network Research HOME Research Researcher JAPANESE Professor CHIBA Natsuko Campus Seiryo campus Laboratory Cancer Biology Tel +81-22-717-8477 E-mail natsuko.chiba.c7＠tohoku.ac.jp I have been involved in clinical oncology in addition to basic research. Using this experience, I would like to contribute to the further understanding of carcinogenesis and to the development of novel cancer therapies. Career March 1997 M.D. Tohoku University School of Medicine March 1997 Ph.D. Tohoku University Graduate School of Medicine April 1997-March 1998 Lecturer, Institute of Development, Aging and Cancer, Tohoku University April 1998- March 1999 Medical Staff in Internal Medicine, Ishinomaki Red-Cross Hospital April 1999- March 2002 Research Fellow in the laboratory of Dr. Jeffrey D. Parvin, Department of Pathology, Brigham and Women’s Hospital, Boston, U.S.A. April 2002-July 2003 Medical Staff in Clinical Oncology, Tohoku University Hospital August 2003-March 2007 Assistant Professor, Department of Clinical Oncology, Institute of Development, Aging and Cancer, Tohoku University April 2007 Associate Professor, Department of Molecular Immunology, Institute of Development, Aging and Cancer, Tohoku University April 2014-present Professor, Department of Cancer Biology, Institute of Development, Aging and Cancer, Tohoku University Selected Publications Matsuzawa A, Kanno S, Nakayama M, Mochiduki H, Wei L, Shimaoka T, Furukawa Y, Kato K, Shibata S, Yasui A, Ishioka C, and Chiba N. The BRCA1/BARD1-interacting protein OLA1 functions in centrosome regulation. Molecular Cell, 53(1):101-104, 2014 Kais Z, Chiba N, Ishioka C, Parvin J D. Functional differences among BRCA1 missense mutations in the control of centrosome duplication. Oncogene, 9;31(6):799-804, 2012 Wei L, Lan L, Yasui A, Tanaka K, Saijo M, Matsuzawa A, Kashiwagi R, Maseki E, Hu Y, Parvin J D, Ishioka C and Chiba N. BRCA1 contributes to transcription-coupled repair of DNA damage through polyubiquitination and degradation of Cockayne syndrome B protein. Cancer Science 102(10):1840-7, 2011 Ransburgh D*, Chiba N*, Toland A, and Parvin J D. (*co-first author) The effect of BRCA1 missense mutations on homology directed recombination. Cancer Research 70(3);988-95, 2010 Wei L, Lan L, Hong Z, Yasui A, Ishioka C, and Chiba N. Rapid recruitment of BRCA1 to DNA double-strand breaks is dependent on its association with Ku80. Mol. Cell. Biol. 28(24); 7380-93, 2008 Activities in Academic Societies The Molecular Biology Society of Japan, Japanese Cancer Association, Japan Society of Clinical Oncology, Japanese Society of Medical Oncology, Japan HBOC Consortium Recent Activities Germline mutations in the Breast cancer associated gene 1 (BRCA1) predispose women to breast and ovarian cancers. BRCA1 is involved in many cellular processes, including DNA repair and centrosome regulation. Defects in the regulatory mechanisms of centrosomes and DNA repair result in defective mitosis, chromosome segregation errors, and the accumulation of DNA damage. These are significant sources of genome instability, a hallmark of cancer. Although the functions of BRCA1 in the DNA repair pathway have been extensively studied, the mechanism of centrosome regulation by BRCA1 is largely unknown. Recently, we identified a novel BRCA1-related protein, Obg-like ATPase 1 (OLA1), which functions in centrosome regulation together with BRCA1. The breast cancer-derived OLA1 mutation does not bind to BRCA1 and fails to rescue the OLA1 knockdown-induced centrosome amplification. The familial breast cancer-derived BRCA1 mutation I42V abrogates the binding of BRCA1 to OLA1. These findings suggest that OLA1 plays a role in centrosome duplication and functions as a tumor suppressor together with BRCA1. To analyze the further functions of BRCA1 and its related proteins, we perform cytological analyses, analyses using genetically modified mice, and analyses of clinical specimens. These researches will contribute to the further understanding of carcinogenesis and to the development novel cancer therapies Fig. 1 Centrosome amplification by knockdown of OLA1. Fig. 2 Accumulation of BRCA1 at the sites of DNA damage. Message to Students Every bridge you cross brings you to a higher level of fulfillment! ResearchLaboratories Department of Integrative Life Sciences Department of Ecological Developmental Adaptability Life Sciences Department of Molecular and Chemical Life SciencesResearchAward GO TOP Graduate School of Life SciencesTohoku University 2-1-1 Katahira, Aoba-Ku, Sendai 980-8577 Academic Affairs Section Tel : +81-22-217-5706 / Fax: +81-22-217-5704   General Affairs Section Tel : +81-22-217-5702 / Fax: +81-22-217-5704   Contact ・Privacy Policy HOMEAbout UsAbout UsMessage from the DeanOrganizationMovieResearchLaboratories Department of Integrative Life Sciences Department of Ecological Developmental Adaptability Life Sciences Department of Molecular and Chemical Life SciencesResearchAwardEducationDegree ProgramsCourseSyllabusScheduleStudent LifeAdmissionAdmission InformationApplicationExamination Schedule and Application GuidelinesInformation Session(2024)Admission and Tuition FeesAdmission PolicyVoices from Graduates and Current StudentsAdmissions Q&AInquiries about Entrance ExaminationsFinancial SupportFor StudentsGraduate School&＃039;s Message Board for Students Information about Completion and Advancement to the Doctoral Course ProceduresCertificatesAbout Issuance of Various CertificatesNotice Regarding the Suspension of Operation of the Automatic Certificate Issuing MachinesLeave of absence/withdrawal from universityCampus Life, Various consultation servicesContactAccessLinkSitemapInformationAdmissionResearchAwardSeminarJobNewsAnnouncementOther © 2004-2023 Graduate School of Life Sciences, Tohoku University no cache