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Home About Traditions &＃038; History Careers at YCU Academics Undergraduate Study School of International Liberal Arts School of Economics and Business Administration School of Science School of Data Science School of Medicine School of Medicine: Medical Course School of Medicine: Nursing Course Graduate Study Graduate School of Urban Social and Cultural Studies Graduate School of International Management Graduate School of Nanobioscience Graduate School of Nanobioscience: Department of Materials System Science Graduate School of Nanobioscience: Department of Life and Environmental System Science Graduate School of Data Science Graduate School of Data Science: Department of Data Science Graduate School of Data Science: Department of Health Data Science Graduate School of Medical Life Science Graduate School of Medicine Graduate School of Medicine: Department of Medicine Graduate School of Medicine: Department of Nursing Non-Degree Programs Exchange Program International Clinical Clerkship Research-Only Career Development Support Admissions Research Advanced Medical Research Center Kihara Institute for Biological Research Life at YCU Kanazawa-Hakkei Campus Life Fukuura Campus Life Living in Yokohama Clubs &＃038; Societies Health &＃038; Wellness Global International Affairs Office Exchange Program Partner Institutions Global Cooperation Institute for Sustainable Cities (GCI) 日本語 TsurumiHome News Tsurumi Filter by Categories Tags Authors Show all AllAcademicsAMRCEmergencyFeaturedGlobalHomeResearchwids Allambassador lectureAMRCchemistrycoronavirusCOVID-19covid19datascienceemergency informationHealth Data ScienceHealth-MediacscKihara Institute for Biological Researchnanobioscienceokurayamasars-cov-2school of medicinescienceSentankenTsurumiwidsycumed AllYCU PR OfficeEditorYCU Global 2021-11-22Structure-based screening combined with computational and biochemical analyses identified the inhibitor targeting the binding of DNA Ligase 1 to UHRF1The accumulation of epigenetic alterations is one of the major causes of tumorigenesis. Aberrant DNA methylation patterns cause genome instability and silencing of tumor suppressor genes in various types of tumors. Therefore, drugs that target DNA methylation-regulating factors have great potential for cancer therapy. Do you like it? Read more2021-11-19Cryo-EM reveals Mechanistic Insights into Lipid-facilitated Polyamine Export by Human ATP13A2The cytoplasmic polyamine maintains cellular homeostasis by chelating toxic metal cations, regulating transcriptional activity, and protecting DNA. ATP13A2 was identified as a lysosomal polyamine exporter responsible for polyamine release into the cytosol, and its dysfunction is associated with Alzheimer’s disease and other neural degradation diseases. ATP13A2 belongs to the P5 subfamily of the P-type ATPase family, but its mechanisms remain unknown.Do you like it? Read more2021-10-14Deformation of microtubules regulates translocation dynamics of kinesinMicrotubules, the most rigid components of the cytoskeleton, can be key transduction elements between external forces and the cellular environment. Mechanical forces induce microtubule deformation, which is presumed to be critical for the mechanoregulation of cellular events.Do you like it? Read more2021-08-06Cryo-EM structure of the human MT1-Gi signaling complexMelatonin receptors (MT1 and MT2) transduce inhibitory signaling by melatonin (N-acetyl-5-methoxytryptamine), which is associated with sleep induction and circadian rhythm modulation. Although recently reported crystal structures of ligand-bound MT1 and MT2 elucidated the basis of ligand entry and recognition, the ligand-induced MT1 rearrangement leading to Gi-coupling remains unclear. Do you like it? Read more 123Next page Search ✕ Latest newsActivity of MEXT Scholarship Alumni After Returning to Their Home Country2024-04-25Intraoperative Integrated Diagnostic System for Malignant Central Nervous System Tumors2023-11-21 Research Research News Advanced Medical Research Center Kihara Institute for Biological Research Researcher Database Global International Affairs Office International Student Support Exchange Program Partner Institutions Global Cooperation Institute for Sustainable Cities (GCI) GCI: Overview GCI: Activities International Academic Consortium for Sustainable Cities (IACSC) Living in Yokohama Admissions 22-2 Seto, Kanazawa-ku, Yokohama, Kanagawa 236-0027 Japan Undergraduate Schools International Liberal Arts Economics and Business Administration Science Data Science Medicine Graduate Schools Urban Social and Cultural Studies International Management Nanobioscience Medical Life Science Medicine  Data Science Admissions Undergraduate Graduate Non-Degree Programs Research Advanced Medical Research Center Kihara Institute for Biological Research Research Database Hospitals Yokohama City University Hospital Yokohama City University Medical Center Life at YCU Campus Life Living in Yokohama Clubs & Societies Health & Wellness Global International Affairs Office Global Cooperation Institute for Sustainable Cities Exchange Programs Partner Institutions NewsActivity of MEXT Scholarship Alumni After Returning to Their Home Country2024-04-25Simplifying the Estimation of Volatile Organic Compounds Emitted From Wildfires2023-10-26Event Report: The 14th IACSC International Symposium/General Assembly2023-10-10 © 2021 Yokohama City University. 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