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Researchers Details of a Researcher Home Japanese このページはJavascriptを使用しています。すべての機能を使用するためにはJavascript を有効にする必要があります。 　 Personnel Information 　 Profile 　 Degree 　 Research Interests 　 Research Areas 　 From School 　 From Graduate School 　 Studying abroad experiences 　 External Career 　 Professional Memberships 　 Qualification Acquired 　 Research Activity 　 Papers 　 Presentations 　 Awards 　 Scientific Research Funds Acquisition Results 　 Education Activity 　 Teaching Experience 　 Contribution to Society 　 Committee Memberships Updated on 2023/02/13 UEMURA Takeshi Affiliation Faculty of Pharmaceutical Sciences Department of Pharmaceutical Sciences External Link To the head of this page.▲ Degree 【 display / non-display 】 To the head of this page.▲ Degree 【 display / non-display 】 博士（医薬学） ( 2005.03   千葉大学 ) 学士（薬学） ( 2000.03   東邦大学 ) 修士（臨床薬学） ( 2000.03   千葉大学 ) To the head of this page.▲ Research Interests 【 display / non-display 】 To the head of this page.▲ Research Interests 【 display / non-display 】 senescence polyamine To the head of this page.▲ Research Areas 【 display / non-display 】 To the head of this page.▲ Research Areas 【 display / non-display 】 Life Science / Pharmaceutical hygiene and biochemistry To the head of this page.▲ From School 【 display / non-display 】 To the head of this page.▲ From School 【 display / non-display 】 Toho University   Faculty of Pharmaceutical Science   Graduated 1996.04 - 2000.03 　 More details Country：Japan To the head of this page.▲ From Graduate School 【 display / non-display 】 To the head of this page.▲ From Graduate School 【 display / non-display 】 Chiba University   Graduate School, Division of Pharmaceutical Sciences   Doctor&＃39;s Course   Completed 2002.04 - 2005.03 　 More details Country：Japan Chiba University   Graduate School, Division of Pharmaceutical Sciences   Master&＃39;s Course   Completed 2000.04 - 2002.03 　 More details Country：Japan To the head of this page.▲ Studying abroad experiences 【 display / non-display 】 To the head of this page.▲ Studying abroad experiences 【 display / non-display 】 2007.10 - 2012.03   University of Arizona, Arizona Cancer Center   Postdoctoral Research Fellow To the head of this page.▲ External Career 【 display / non-display 】 To the head of this page.▲ External Career 【 display / non-display 】 Kyoto Prefectural University of Medicine   Part-time researcher for university or other academic organization 2014.10 　 More details Country：Japan Chiba University   Part-time researcher for university or other academic organization 2014.10 - 2021.03 　 More details Country：Japan 株式会社アミンファーマ研究所   主任研究員 2014.10 - 2021.03 　 More details Country：Japan Kyoto Prefectural University of Medicine   Assistant Professor 2012.04 - 2014.09 　 More details Country：Japan University of Arizona   Arizona Cancer Center   Researcher 2007.10 - 2012.03 　 More details Country：United States display all >> To the head of this page.▲ Professional Memberships 【 display / non-display 】 To the head of this page.▲ Professional Memberships 【 display / non-display 】 日本分子生物学会 2019.04 American Society for Biochemistry and Molecular Biology 2019.02 日本ポリアミン学会 2010.06 日本生化学会 2004.04 日本薬学会 2002.04 To the head of this page.▲ Qualification Acquired 【 display / non-display 】 To the head of this page.▲ Qualification Acquired 【 display / non-display 】 TOEIC（730） Pharmacist To the head of this page.▲   Papers 【 display / non-display 】 To the head of this page.▲ Papers 【 display / non-display 】 Correlation of polyamines, acrolein-conjugated lysine and polyamine metabolic enzyme levels with age in human liver. Reviewed Uemura Takeshi, Akasaka Yoshihisa, Ikegaya Hiroshi Heliyon   6 ( 9 )   e05031 - e05031   2020.09 　More details Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   The polyamines spermidine, spermine and putrescine are essential for normal cellular functions. The contents of polyamines in tissue decreased in aged mice compared to young mice. In this study, the polyamine contents and their metabolic byproduct acrolein-conjugated lysine (N (ε)-(3-formyl-3,4-dehydropiperidino)-lysine, FDP-Lys) in human liver tissue were measured and analyzed the correlation with age of the subjects. The putrescine and FDP-Lys levels were significantly increased with age. On the other hand, spermine level was decreased with age. Spermidine did not significantly correlate with age. The relative amount of spermine oxidase (SMOX) significantly correlated with the age of subjects whereas ornithine decarboxylase (ODC) and adenosylmethionine decarboxylase (AMD1) significantly reduced by the age. Our results suggested that an increase in oxidation and reduction in polyamine synthesis may cause the change of polyamine profile in the elderly. DOI： 10.1016/j.heliyon.2020.e05031 PubMed A search for acrolein scavengers among food components Reviewed Uemura T, Uchida M, Nakamura M, Shimekake M, Sakamoto A, Terui Y, Higashi K, Ishii I, Kashiwagi K, Igarashi K. Amino Acids   2023.02 　More details Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)   Nα-(5-Fluoro-2,4-dinitrophenyl)-L-leucinamide-derivatized LC/MS/MS Analysis of Amino Acid Enantiomers in HepG2 Cells Reviewed Takano Y, Takahashi M, Kobayashi M, Uemura T, Furuchi T. Chromatography   42 ( 3 )   143 - 149   2021 　More details Language：English   Publishing type：Research paper (scientific journal)   Structural change and degradation of cytoskeleton due to the acrolein conjugation with vimentin and actin during brain infarction. Reviewed Uemura Takeshi, Suzuki Takehiro, Ko Kenta, Nakamura Mizuho, Dohmae Naoshi, Sakamoto Akihiko, Terui Yusuke, Toida Toshihiko, Kashiwagi Keiko, Igarashi Kazuei Cytoskeleton (Hoboken)   77 ( 10 )   414 - 421   2020.10 　More details Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)   We have found recently that dendritic spine extension is inhibited through acrolein conjugation with α- and β-tubulin proteins during brain infarction. In this current study, we looked for other acrolein-conjugated proteins in the 100,000g precipitate fraction, to clarify how cytoskeleton structure is modified by acrolein. Acrolein-conjugated proteins were sought from acrolein-treated mouse FM3A and Neuro2a cells and from tissues isolated from mouse brain infarction. It was found that vimentin was conjugated with acrolein, and the conjugated amino acid residue was Cys328, which is the only Cys residue in vimentin. It was also found that Cys207, 257, 285, and Lys118 in actin, another cytoskeleton protein, were conjugated with acrolein. The structure and localization of vimentin and actin filaments were changed greatly in infarct brain in photochemically induced thrombosis model mice and in acrolein-treated Neuro2a cells. In addition, degradation of cytoskeleton proteins was accelerated in the order vimentin > tubulin > actin in mouse brain infarction. These findings indicate that a dysfunction of the cytoskeleton by acrolein is strongly involved in the tissue damage during brain infarction, together with the apoptosis caused by glyceraldehyde-3-phosphate dehydrogenase and protein degradation by matrix metalloproteinase-9. DOI： 10.1002/cm.21638 PubMed Urinary Amino Acid-Conjugated Acrolein and Taurine as New Biomarkers for Detection of Dementia Reviewed Yoshida M, Uemura T, Mizoi M, Waragai M, Sakamoto A, Terui Y, Kashiwagi K, Igarashi K. J Alzheimers Dis.   2023.01 　More details Authorship：Second author   Language：English   Publishing type：Research paper (scientific journal)   display all >> To the head of this page.▲ Presentations 【 display / non-display 】 To the head of this page.▲ Presentations 【 display / non-display 】 Aging associated change in polyamine metabolism Invited International conference Takeshi Uemura, Yuka Yokota, Miki Matsunaga, Yoshihisa Akasaka, Koichi Takao, Hiroshi Ikegaya, Takemitsu Furuchi Sixth International Conference on Polyamines: Biochemical, Physiological and Clinical Perspectives  2022.09  Enzo Agostinelli 　More details Event date： 2022.09 Language：English   Presentation type：Oral presentation (general)   Venue：Tivoli, Rome   Country：Italy   To the head of this page.▲ Awards 【 display / non-display 】 To the head of this page.▲ Awards 【 display / non-display 】 博慈会　ダ・ビンチ賞 2018.11   博慈会   植村武史 　More details Award type：Honored in official journal of a scientific society, scientific journal  Country：Japan To the head of this page.▲ Scientific Research Funds Acquisition Results 【 display / non-display 】 To the head of this page.▲ Scientific Research Funds Acquisition Results 【 display / non-display 】 タンパク質翻訳合成およびアミン類代謝経路の補正による抗老化機構の解明 Grant number：22H03515  2022.04 - 2024.03 基盤研究(B) 　 More details Authorship：Coinvestigator(s)  Grant type：Competitive ポリアミンが誘導するリピート病の発症機構とその制御による病態抑制効果の解明 Grant number：22K07357  2022.04 - 2024.03 基盤研究(C) 　 More details Authorship：Coinvestigator(s)  Grant type：Competitive 加齢によるスペルミン分解活性化機構解明と新規抗老化物質の創出 Grant number：22K11860  2022.04 - 2024.03 基盤研究(C) 　 More details Authorship：Principal investigator  Grant type：Competitive To the head of this page.▲   Teaching Experience 【 display / non-display 】 To the head of this page.▲ Teaching Experience 【 display / non-display 】 中毒学 医学研究方法概論 Institution：Kyoto Prefectural University of Medicine 分析化学III Institution：Chiba University 法医学 Institution：Kyoto Prefectural University of Medicine 法医学実習 Institution：Kyoto Prefectural University of Medicine display all >> To the head of this page.▲   Committee Memberships 【 display / non-display 】 To the head of this page.▲ Committee Memberships 【 display / non-display 】 日本ポリアミン学会   企画運営委員会委員、学会誌編集委員   2014.10    　 More details Committee type：Academic society To the head of this page.▲   Copyright © Josai University, All Rights Reserved.