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-->   shigehiro ohdo Last modified date：2024.05.05 Specially-appointed Professor / Clinical Pharmacy Department of Pharmaceutical Health Care and Sciences Faculty of Pharmaceutical Sciences 1 Research Interests 2 Academic Activities 2.1 Books 2.2 Papers 2.3 Reports 2.4 Presentations 3 Other Educational Activities Graduate School Department of Clinical Pharmacy Graduate School of Pharmaceutical Sciences Undergraduate School Department of Clinical Pharmacy School of Pharmaceutical Sciences Other Organization Pharmacy Administration Post Dean of the Faculty of Pharmaceutical Sciences E-Mail　*Since the e-mail address is not displayed in Internet Explorer, please use another web browser:Google Chrome, safari. Homepage https://kyushu-u.elsevierpure.com/en/persons/shigehiro-ohdo　Reseacher Profiling Tool　Kyushu University Pure http://yakuzai.phar.kyushu-u.ac.jpThe study on the individualization of pharmacotherapy has been carried out aiming at further improvement of pharmacotherapy. However, intraindividual variability as well as interindividual variability should be considered to aim at further improvement of rational pharmacotherapy. Because many drugs vary in potency and/or toxicity associated with the rhythmicity of biochemical, physiological and behavioral processes. One approach to increasing the efficiency of pharmacotherapy is the administration of drugs at times at which they are most effective and/or best tolerated. The application of biological rhythm to pharmacotherapy may be accomplished by the appropriate timing of conventionally formulated tabletes and capsules, and the special drug delivery system to synchronize drug concentrations to rhythms in disease activity. In all living organisms, circadian pacemaker resides in the paired suprachiasmatic nuclei (SCN). Clock genes are the genes that control the circadian rhythms in physiology and behavior. The knowledge of clock genes may be important for the clinical practice. Therefore, we aim at the development of new chronotherapy based on the following strategy: to monitor a rhythmic marker for selecting dosing time, to overcome the alteration of the clock function, a new concept of adverse effects, by devising a dosing schedule and to produce new rhythmicity by manipulating the conditions of living organs by using rhythmic administration of altered feeding schedules or several drugs. . Phone 092-642-6610 Fax 092-642-6614 Academic Degree Doctor of philosophy Country of degree conferring institution (Overseas) No Field of Specialization pharmaceutics, chronopharmacology Total Priod of education and research career in the foreign country 01years00months Outline Activities The study on the individualization of pharmacotherapy has been carried out aiming at further improvement of pharmacotherapy. However, intraindividual variability as well as interindividual variability should be considered to aim at further improvement of rational pharmacotherapy. Because many drugs vary in potency and/or toxicity associated with the rhythmicity of biochemical, physiological and behavioral processes. One approach to increasing the efficiency of pharmacotherapy is the administration of drugs at times at which they are most effective and/or best tolerated. The application of biological rhythm to pharmacotherapy may be accomplished by the appropriate timing of conventionally formulated tabletes and capsules, and the special drug delivery system to synchronize drug concentrations to rhythms in disease activity. In all living organisms, circadian pacemaker resides in the paired suprachiasmatic nuclei (SCN). Clock genes are the genes that control the circadian rhythms in physiology and behavior. The knowledge of clock genes may be important for the clinical practice. Therefore, we aim at the development of new chronotherapy based on the following strategy: to monitor a rhythmic marker for selecting dosing time, to overcome the alteration of the clock function, a new concept of adverse effects, by devising a dosing schedule and to produce new rhythmicity by manipulating the conditions of living organs by using rhythmic administration of altered feeding schedules or several drugs. Research Research Interests Development of new chronotherapy based on molecular clockkeyword : circadian rhythm, clock gene, chronopharmacology, chronopharmaceutics1990.08～2016.03The study on the individualization of pharmacotherapy has been carried out aiming at further improvement of pharmacotherapy. However, intraindividual variability as well as interindividual variability should be considered to aim at further improvement of rational pharmacotherapy. Because many drugs vary in potency and/or toxicity associated with the rhythmicity of biochemical, physiological and behavioral processes. One approach to increasing the efficiency of pharmacotherapy is the administration of drugs at times at which they are most effective and/or best tolerated. The application of biological rhythm to pharmacotherapy may be accomplished by the appropriate timing of conventionally formulated tabletes and capsules, and the special drug delivery system to synchronize drug concentrations to rhythms in disease activity. In all living organisms, circadian pacemaker resides in the paired suprachiasmatic nuclei (SCN). Clock genes are the genes that control the circadian rhythms in physiology and behavior. The knowledge of clock genes may be important for the clinical practice. Therefore, we aim at the development of new chronotherapy based on the following strategy: to monitor a rhythmic marker for selecting dosing time, to overcome the alteration of the clock function, a new concept of adverse effects, by devising a dosing schedule and to produce new rhythmicity by manipulating the conditions of living organs by using rhythmic administration of altered feeding schedules or several drugs.. Academic Activities Books  Show All Books >> Reports  Show All Reports >> Papers  Show All Papers >> Presentations  Show All Presentations >> Educational Other Educational Activities 2010.04. 2006.09. 2006.05. 2005.09. Unauthorized reprint of the contents of this database is prohibited. Copyright © 2006, Kyushu University. All rights reserved.