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20090915--> ID: Pass: Lost Password? / Register Now! --> 20090915--> --> The NI technologies for the collection and sharing of Neuro-related data are important for the brain understanding. These information include electrical resources, papers, experimental data, mathematical models, simulations, URLs, etc. Hence, it is necessary to develop a database system to integrate these disparate resources into a single base named XooNIps, which serves as the Base Platform for each research fields. 20090915--> Home News Forum 20090915--> Advanced Search--> Login XooNIps検索    全て タイトル & キーワード メタデータ Article      詳細検索 インデックスツリー open all close all Public 全て タイトル & キーワード メタデータ Article --> 詳細 閲覧数:1849 ID AN00181569-19871200-1001 アイテムタイプ Article このアイテムを表示する 画像 本文 AN00181569-19871200-1001.pdf Type : application/pdf Size : 151.4 KB Last updated : Nov 8, 2010 Downloads : 890 Total downloads since Nov 4, 2010 : 892 タイトル Synthesis of the Disaccharides of Phenolic Glycolipid I of Mycobacterium leprae with Some Kinds of Aglycone and Their Serological Activities 著者 藤原 剛 (Fujiwara tsuyoshi) 教養部 和泉 真蔵 (izumi shinzo) 教養部 版 publisher 出版地 奈良 出版者 奈良大学 上位タイトル 奈良大学紀要 (Memoirs of the Nara University). Vol.16号, (1987. 12) ,p.1- 10 識別番号 ISSN 03892204 抄録 The bromide of the peracetate of the non-reducing-end disaccharide of phenolic glycolipid I of Mycobacterium leprae was coupled with lauryl alcohol or 3-phenylpropanol in acetonitrile in the presence of mercury cyanide. The product was the 1:1 mixture of α-and β-1inked disaccharides. The coupling of the bromide with stearyl alcohol in nitromethane-toluene gave mainly α―linked stearyl disaccharide. The complete loss of the stereoselectivity in acetonitrile was thought to be due to the lack of neibouring group participation. The activities of these disaccharides and some other synthetic disaccharides were tested in ELISA inhibition assay and direct ELISA. No compound tested in this study showed lower activity than free disaccharide in ELISA inhibition assay. Among the tested disaccharides, the compounds with long lipophilic chain as lauryl and stearyl disaccharides showed high activity in both ELISA inhibition assay and direct ELISA. On the other hand the compounds with short chain showed only the same level of the activity as that of free disaccharide in ELISA inhibition assay. And these compounds showed no activity in direct ELISA. These results suggest that long lipophilic compounds like lauryl or stearyl alcohol should be chosen for the development of the synthetic antigen convenient for direct ELISA. 言語 eng 資源タイプ text ジャンル Departmental Bulletin Paper Index / Public / 奈良大学紀要 / 16号 関連アイテム