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入学希望の方一般・社会人の方研究者の方同窓生の方在学生の方教職員の方 日本語 (Japanese) Graduate School of Life Sciences, Tohoku University Access sitemap Link Tohoku University HOMEAbout UsAbout UsMessage from the DeanOrganizationMovieResearchLaboratories Department of Integrative Life Sciences Department of Ecological Developmental Adaptability Life Sciences Department of Molecular and Chemical Life SciencesResearchAwardEducationDegree ProgramsCourseSyllabusScheduleStudent LifeAdmissionAdmission InformationApplicationExamination Schedule and Application GuidelinesInformation Session(2024)Admission and Tuition FeesAdmission PolicyVoices from Graduates and Current StudentsAdmissions Q&AInquiries about Entrance ExaminationsFinancial SupportFor StudentsGraduate School&＃039;s Message Board for Students Information about Completion and Advancement to the Doctoral Course ProceduresCertificatesAbout Issuance of Various CertificatesNotice Regarding the Suspension of Operation of the Automatic Certificate Issuing MachinesLeave of absence/withdrawal from universityCampus Life, Various consultation servicesContactAccessLinkSitemapInformationAdmissionResearchAwardSeminarJobNewsAnnouncementOther MENU HOMEAbout UsAbout UsMessage from the DeanOrganizationMovieResearchLaboratoriesResearchAwardEducationDegree ProgramsCourseSyllabusScheduleStudent LifeAdmissionAdmission InformationApplicationExamination Schedule and Application GuidelinesInformation Session(2024)Admission and Tuition FeesAdmission PolicyVoices from Graduates and Current StudentsAdmissions Q&AInquiries about Entrance ExaminationsFinancial SupportFor StudentsGraduate School&＃039;s Message Board for Students Information about Completion and Advancement to the Doctoral Course ProceduresCertificatesLeave of absence/withdrawal from universityCampus Life, Various consultation servicesContactAccessLinkSitemapInformationAdmissionResearchAwardSeminarJobNewsAnnouncementOther 日本語 (Japanese) CLOSE Graduate School of Life Sciences, Tohoku University. Field Molecular and Chemical Life Science :Cooperative faculties Research HOME Research Researcher JAPANESE Professor MOTOHASHI Hozumi Campus Seiryo campus Laboratory Redox Biology Tel +81-22-717-8089 E-mail hozumim＠med.tohoku.ac.jp Website https://sites.google.com/view/motohashi-lab/home ResearchMap https://researchmap.jp/read0138537/ I was born in Kagoshima and brought up in Sendai. After graduating from medical school, I got a training as an ENT doctor for 2 years. During my PhD course, I was fascinated with intricate regulatory mechanisms of transcriptional regulation and decided to switch my major to biochemistry. A main target of my current research is a redox-responsive transcription factor NRF2. My goal is to clarify in vivo contribution of NRF2 to various aging-related diseases, including cancer, chronic inflammation and neurodegeneration. Selected Publications Akaike T, Ida T, Wei FY, Nishida M, Kumagai Y, Alam MM, Ihara H, Sawa T, Matsunaga T, Kasamatsu S, Nishimura A, Morita M, Tomizawa K, Nishimura A, Watanabe S, Inaba K, Shima H, Tanuma N, Jung M, Fujii S, Watanabe Y, Ohmuraya M, Nagy P, Feelisch M, Fukuto JM, Motohashi H.  Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics.  Nat Commun 8, 1177, 2017. Kitamura H, Onodera Y, Murakami S, Suzuki T, Motohashi H.  IL-11 contribution to tumorigenesis in an NRF2 addiction cancer model.  Oncogene 36, 6315-6324, 2017. Kobayashi EH, Suzuki T, Funayama R, Nagashima T, Hayashi M, Sekine H, Tanaka N, Moriguchi T, Motohashi H, Nakayama K, Yamamoto M.  NRF2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription.  Nat Commun 7, 11624, 2016. Shirasaki K, Taguchi K, Unno M, Motohashi H, Yamamoto M.  Nrf2 promotes compensatory liver hypertrophy after portal vein branch ligation in mice.  Hepatology 59, 2371-2382, 2014. Mitsuishi Y, Taguchi K, Kawatani Y, Shibata T, Nukiwa T, Aburatani H, Yamamoto M, Motohashi H.  Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming.  Cancer Cell 22, 66-79, 2012.  Motohashi H, Kimura M, Fujita R, Inoue A, Pan X, Takayama M, Katsuoka F, Aburatani H, Bresnick EH, Yamamoto M.  NF-E2 domination over Nrf2 promotes ROS accumulation and megakaryocytic maturation.  Blood 115, 677-686, 2010.  Komatsu M, Kurokawa H, Waguri S, Taguchi K, Kobayashi A, Ichimura Y, Sou Y.-S., Ueno I, Sakamoto A, Tong KI, Kim M, Nishito Y, Iemura S.-i., Natsume T, Ueno T, Kominami E, Motohashi H, Tanaka K, Yamamoto M.  The selective autophagy substrate p62 activates the stress response transcription factor Nrf2 through inactivation of Keap1.  Nat Cell Biol 12, 213-223, 2010. Motohashi H, Katsuoka F, Engel JD, Yamamoto M.  Small Maf proteins serve as transcriptional cofactors for keratinocyte differentiation in the Keap1-Nrf2 regulatory pathway.  Proc Natl Acad Sci USA 101, 6379-6384, 2004. Kusunoki H, Motohashi H, Katsuoka F, Morohashi A, Yamamoto M and Tanaka T.  Solution structure of the DNA-binding domain of MafG.  Nat Struct Biol 4, 252-256, 2002. Motohashi H, Katsuoka F, Shavit JA, Engel JD, Yamamoto M.  Positive or negative MARE-dependent transcriptional regulation is determined by the abundance of small Maf proteins.  Cell 103, 865-875, 2000.  Activities in Academic Societies A member of Japanese Biochemical Society, Japanese Cancer Association, The Molecular Biology Society of Japan, and Society for Free Radical Research Japan.  Teaching Transcriptional regulation in response to redox imbalance Glucose metabolism and OXPHOS   Recent Activities A current major question in my lab is how the redox regulation contributes to the process of organismal aging.  Our hypothesis is that impaired environmental response and subsequent smoldering inflammation are two essential components of aged phenotypes.  To prove this hypothesis, we are conducting various experiments described below.   　(1)  Impaired environmental response Interaction with environments is a critical determinant of organismal aging processes.  Many of the environmental stresses alter the cellular redox balance, which eventually results in the organ dysfunction of aged individuals.  We are interested in the relation between anti-aging effects of habitual exercise and NRF2 function.  NRF2-driven metabolic reprogramming for energy production is one of the important themes in our current studies.    　(2)  Smoldering inflammation We are focusing on Alzheimer’s disease and chronic obstructive pulmonary disease (COPD), which are two major aging-related diseases.  We recently clarified that NRF2 has a potent anti-inflammatory activity and effectively alleviates a lethal autoimmune disease caused by Treg deficiency (Suzuki et al, Mol Cell Biol 2017).  Multiple experimental approaches are being taken for elucidating molecular mechanisms of NRF2-mediated suppression of inflammation.   Message to Students If you find a new reaction, always be aware how it is important in vivo.  There could be a lot of peculiar and novel phenomena you can find.  But it is very important to characterize the phenomena in the biological context because our ultimate goal is achievement of healthy aging of human beings.   ResearchLaboratories Department of Integrative Life Sciences Department of Ecological Developmental Adaptability Life Sciences Department of Molecular and Chemical Life SciencesResearchAward GO TOP Graduate School of Life SciencesTohoku University 2-1-1 Katahira, Aoba-Ku, Sendai 980-8577 Academic Affairs Section Tel : +81-22-217-5706 / Fax: +81-22-217-5704   General Affairs Section Tel : +81-22-217-5702 / Fax: +81-22-217-5704   Contact ・Privacy Policy HOMEAbout UsAbout UsMessage from the DeanOrganizationMovieResearchLaboratories Department of Integrative Life Sciences Department of Ecological Developmental Adaptability Life Sciences Department of Molecular and Chemical Life SciencesResearchAwardEducationDegree ProgramsCourseSyllabusScheduleStudent LifeAdmissionAdmission InformationApplicationExamination Schedule and Application GuidelinesInformation Session(2024)Admission and Tuition FeesAdmission PolicyVoices from Graduates and Current StudentsAdmissions Q&AInquiries about Entrance ExaminationsFinancial SupportFor StudentsGraduate School&＃039;s Message Board for Students Information about Completion and Advancement to the Doctoral Course ProceduresCertificatesAbout Issuance of Various CertificatesNotice Regarding the Suspension of Operation of the Automatic Certificate Issuing MachinesLeave of absence/withdrawal from universityCampus Life, Various consultation servicesContactAccessLinkSitemapInformationAdmissionResearchAwardSeminarJobNewsAnnouncementOther © 2004-2023 Graduate School of Life Sciences, Tohoku University no cache