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Skip to content Dept. Gene Expression Regulation   Professor Hozumi MOTOHASHI, MD PhD The Department of Gene Expression Regulation focuses on the transcriptional regulation of gene expression that is important for the maintenance of homeostasis. We are also interested in the maintenance of redox homeostasis within the nucleus and the contribution of Nrf2-sMaf to its protection from intrinsic genotoxicity. Our goal is to understand the molecular basis of various pathological conditions related to the aging process from the viewpoint of transcriptional regulation by Nrf2-sMaf and its related factors. Research Topics: •Transcriptional regulation for metabolic reprogramming and stress response in cancer cells. •Intranuclear redox balance and genome protection in carcinogenesis. •Stress response and epigenetic memory of hematopoietic stem cells in chronic inflammation.   About Us IDAC’s Mission Statement Greeting &＃038; Mission Notable Alumni History of IDAC IDAC&＃8217;s Affiliations News &＃038; Events Research Facilities &＃038; Faculty Research Facilities Common Facilities Resources &＃038; Equipment Brain Imaging Cell Center Equipment Admission &＃038; Courses Mechanisms of Aging Overcoming Intractable Cancers Overcoming Age-Related Brain Diseases Achieving &＃8220;Smart-Aging&＃8221; Public Relations &＃038; Info. Office Maps &＃038; Directions Give to IDAC Contact Us Privacy Policy &＃038; Disclaimer IDAC COVID-19 Update Navi About Us IDAC’s Mission Statement Greeting &＃038; Mission Notable Alumni History of IDAC IDAC&＃8217;s Affiliations News &＃038; Events Research Facilities &＃038; Faculty Research Facilities Common Facilities Resources &＃038; Equipment Brain Imaging Cell Center Equipment Admission &＃038; Courses Mechanisms of Aging Overcoming Intractable Cancers Overcoming Age-Related Brain Diseases Achieving &＃8220;Smart-Aging&＃8221; Public Relations &＃038; Info. Office Maps &＃038; Directions Give to IDAC Contact Us Privacy Policy &＃038; Disclaimer IDAC COVID-19 Update Navi ©Institute of Development, Aging and Cancer, Tohoku University