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-->   Matsuda Taito Last modified date：2024.05.07 Lecturer / Department of Stem Cell Biology and Medicine Faculty of Medical Sciences 1 Research Interests 2 Academic Activities 2.1 Papers 2.2 Reports 3 Membership in Academic Society E-Mail　*Since the e-mail address is not displayed in Internet Explorer, please use another web browser:Google Chrome, safari. Homepage https://kyushu-u.elsevierpure.com/en/persons/taito-matsuda　Reseacher Profiling Tool　Kyushu University Pure Phone 092-642-6196 Fax 092-642-6561 Academic Degree Doctor of Medicine Country of degree conferring institution (Overseas) No Field of Specialization Neuroscience Total Priod of education and research career in the foreign country 00years00months Research Research Interests Direct reprogramming of microglia into neurons keyword : direct reprogramming2018.04～2021.05. Identify the factors inducing the impairment of neural stem cell proliferation during agingkeyword : Neural stem cell2018.04～2022.05. Academic Activities Reports  Show All Reports >> Papers  Show All Papers >> 1. Takashi Irie, Taito Matsuda*, Yoshinori Hayashi, Kanae Matsuda-Ito, Akihide Kamiya, Takahiro Masuda, Marco Prinz, Noriko Isobe, Jun-ichi Kira, and Kinichi Nakashima*, Direct neuronal conversion of microglia/macrophages reinstates neurological function after stroke, Proc Natl Acad Sci USA, https://doi.org/10.1073/pnas.230797212, 2024.05. 2. Matsuda T * (co-corresponding author)., Irie T., Katsurabayashi S., Hayashi Y., Nagai T., Hamazaki N., Adefuin AMD., Miura F., Ito T., Kimura H., Shirahige K., Takeda T., Iwasaki K., Imamura T. & Nakashima K*., Pioneer Factor NeuroD1 Rearranges Transcriptional and Epigenetic Profiles to Execute Microglia-Neuron Conversion, Neuron, 101, 472-485, 2019.01, Minimal sets of transcription factors can directlyreprogram somatic cells into neurons. However,epigenetic remodeling during neuronal reprogram-ming has not been well reconciled with transcrip-tional regulation. Here we show that NeuroD1achieves direct neuronal conversion from mouse mi-croglia bothin vitroandin vivo. Exogenous NeuroD1initially occupies closed chromatin regions associ-ated with bivalent trimethylation of histone H3 atlysine 4 (H3K4me3) and H3K27me3 marks in micro-glia to induce neuronal gene expression. These re-gions are resolved to a monovalent H3K4me3 markat later stages of reprogramming to establish theneuronal identity. Furthermore, the transcriptionalrepressorsScrt1andMeis2are induced as NeuroD1target genes, resulting in a decrease in the expres-sion of microglial genes. In parallel, the microglialepigenetic signature in promoter and enhancerregions is erased. These findings reveal NeuroD1pioneering activity accompanied by global epige-netic remodeling for two sequential events: onset ofneuronal property acquisition and loss of the micro-glial identity during reprogramming.. Membership in Academic Society The Japane Neuroscience Sciety The Japanese society for Epigenetics Unauthorized reprint of the contents of this database is prohibited. Copyright © 2006, Kyushu University. All rights reserved.