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Researchers Details of a Researcher Home Japanese このページはJavascriptを使用しています。すべての機能を使用するためにはJavascript を有効にする必要があります。 　 Personnel Information 　 Profile 　 Degree 　 Research Areas 　 From School 　 Studying abroad experiences 　 Employment Record in Research 　 External Career 　 Professional Memberships 　 Qualification Acquired 　 Research Activity 　 Papers 　 Books and Other Publications 　 Misc 　 Presentations 　 Scientific Research Funds Acquisition Results 　 Other External Funds 　 Past of Cooperative Research 　 Contribution to Society 　 Committee Memberships 　 Social Activities Updated on 2023/08/22 KUDO Naomi Affiliation Faculty of Pharmaceutical Sciences Department of Pharmaceutical Sciences Title Professor External Link To the head of this page.▲ Degree 【 display / non-display 】 To the head of this page.▲ Degree 【 display / non-display 】 薬学博士 ( 1992.03   北海道大学 ) To the head of this page.▲ Research Areas 【 display / non-display 】 To the head of this page.▲ Research Areas 【 display / non-display 】 Environmental Science/Agriculture Science / Radiation influence Life Science / Pharmaceutical hygiene and biochemistry Environmental Science/Agriculture Science / Chemical substance influence on environment To the head of this page.▲ From School 【 display / non-display 】 To the head of this page.▲ From School 【 display / non-display 】 Hokkaido University   Faculty of Pharmaceutical Science   Graduated - 1983.03 　 More details Country：Japan To the head of this page.▲ Studying abroad experiences 【 display / non-display 】 To the head of this page.▲ Studying abroad experiences 【 display / non-display 】 1994.05 - 1995.04   University of Alberta   Post Doctoral Fellow To the head of this page.▲ Employment Record in Research 【 display / non-display 】 To the head of this page.▲ Employment Record in Research 【 display / non-display 】 Josai University   Faculty of Pharmaceutical Sciences   Department of Pharmaceutical Sciences   Professor 2011.04 Josai University   Faculty of Pharmaceutical Sciences   Department of Pharmaceutical Sciences   Associate Professor 2007.04 - 2011.03 Josai University   Faculty of Pharmaceutical Sciences   Associate Professor (as old post name) 2006.04 - 2007.03 Josai University   Faculty of Pharmaceutical Sciences   Lecturer 2003.04 - 2006.03 Josai University   Faculty of Pharmaceutical Sciences   Research Assistant 1996.04 - 2003.03 To the head of this page.▲ External Career 【 display / non-display 】 To the head of this page.▲ External Career 【 display / non-display 】 カナダアルバータ州立大学医学部   博士研究員 1994.05 - 1995.04 帝京大学薬学部   助手 1986.04 - 1996.03 帝京大学薬学部   教務職員 1983.04 - 1986.03 To the head of this page.▲ Professional Memberships 【 display / non-display 】 To the head of this page.▲ Professional Memberships 【 display / non-display 】 Japan Radioisotope Association 2007.07 The Japanese Society of Toxicology 2005.01 日本食品衛生学会 2003.04 日本中毒学会 2002.04 日本脂質生化学研究会 1990.04 display all >> To the head of this page.▲ Qualification Acquired 【 display / non-display 】 To the head of this page.▲ Qualification Acquired 【 display / non-display 】 Pharmacist Chief Person of Radiation Handling （first and second kind） To the head of this page.▲   Papers 【 display / non-display 】 To the head of this page.▲ Papers 【 display / non-display 】 Reduction in Secretion of Very Low Density Lipoprotein–Triacylglycerol by a Matrix Metalloproteinase Inhibitor in a Rat Model of Diet-Induced Hypertriglyceridemia Reviewed International journal Yoichi Kawashima, Yoshihiro Eguchi, Tohru Yamazaki, Minako Karahashi, Hiroshi Kawai, and Naomi Kudo Journal of Pharmacology and Experimental Therapeutics   366 ( 7 )   194 - 204   2018.07 　More details Language：English   Publishing type：Research paper (scientific journal)   Publisher：The American Society of Pharmacology and Experimental Therapeutics   Matrix metalloproteinase inhibitors (MMPIs) reduced serum triacylglycerol (TAG) levels in streptozotocin-induced diabetic rats and Zucker fa/fa rats in our previous study. However, the mechanisms underlying TAG reduction by MMPIs remain unclear. The present study aimed to elucidate the mechanism by which F81-1144b, an MMPI, lowers serum TAG levels in an animal model of high-sucrose diet (HSD)-induced hypertriglyceridemia. F81-1144b was repeatedly administered to rats fed HSD, and its effects were evaluated on TAG levels in serum and the liver, very low density lipoprotein (VLDL) secretion, de novo fatty acid (FA) synthesis in the liver, and the expression of genes regulating the metabolism of FA, TAG, and VLDL in the liver and serum. F81-1144b lowered TAG levels in serum and the liver, VLDL-TAG secretion, de novo FA synthesis in the liver, and serum levels of insulin and glucose. F81-1144b suppressed the expression of genes related to the de novo synthesis of FA and TAG, key proteins (lipin 1 and apolipoprotein CIII) responsible for VLDL metabolism, and sterol regulatory element-binding protein-1c and carbohydrate response element-binding protein. F81-1144b little affected the expression of genes related directly to the degradation of TAG or FA, but it upregulated that of gene for uncoupling protein 2 in the liver. These results suggest that MMPIs are a novel type of therapeutic agent for the treatment of hypertriglyceridemia, because the metabolic effects of F81-1144b expected from changes in the expression of genes regulating lipid metabolism would alter metabolism differently from those induced by fibrates, niacin, or n-3 FAs. DOI： 10.1124/jpet.117.246165 Time of Administration of Acute or Chronic Doses of Imipramine Affects its Antidepressant Action in Rats Reviewed International journal Hiroshi Kawai, Natsumi Kodaira, Chika Tanaka, Takuya Ishibashi, Naomi Kudo, YoichiKawashima, Atsushi Mitsumoto Journal of Circadian Rhythms   16   5   2018.05 　More details Language：English   Publishing type：Research paper (scientific journal)   Publisher：Bio Med Central   The pathogenesis and therapeutics of depression are linked to the operation of the circadian system. Here, we studied the chronopharmacological action of a tricyclic antidepressant, imipramine. Male adult Wistar–Hannover rats were administered imipramine acutely or chronically in the morning or in the evening. The antidepressant action of imipramine was analyzed using the forced swim test (FST). A single dose of imipramine (30 mg/kg) in the morning, but not in the evening, reduced immobility and increased climbing in the FST. The plasma concentrations of imipramine and its metabolite, desipramine, were slightly higher in the morning than in the evening, which might explain the dosing time-dependent action of imipramine. Next, we analyzed the effect of chronic imipramine treatment. Rats received imipramine in the morning or in the evening for 2 weeks. The morning treatment resulted in larger effects in the FST than the evening treatment, and was effective at a dose that was ineffective when administered acutely. The levels of brain α-adrenergic receptors tended to decrease after chronic imipramine treatment. Imipramine might interact with noradrenergic neurons, and this interaction might chronically alter receptor expression. This alteration seemed greater in the morning than in the evening, which might explain the dosing time-dependent action of imipramine. DOI： 10.5334/jcr.156 Chronopharmacological Analysis of Antidepressant Activity of a Dual-Action Serotonin Noradrenaline Reuptake Inhibitor (SNRI), Milnacipran, in Rats Reviewed Hiroshi Kawai, Megumi Machida, Takuya Ishibashi, Naomi Kudo, Yoichi Ka ... Biological and Pharmaceutical Bulletin   41 ( 2 )   213 - 219   2018.02 　More details Language：English   Publishing type：Research paper (scientific journal)   Publisher：The Pharmaceutical Sciety of Japan   Biological rhythms are thought to be related to the pathogenesis and therapy of various diseases including depression. Here we investigated the influence of circadian rhythms on the antidepressant activity of the dual-action serotonin-noradrenaline reuptake inhibitor (SNRI) milnacipran. Rats administered milnacipran in the morning (8:00 a.m.; zeitgeber time [ZT]1) or in the evening (8:00 p.m.; ZT13) were analyzed in a forced swim test (FST). At ZT1, the rats’ immobility was reduced and the swimming was increased, whereas at ZT13, their climbing was increased. These results suggest that the serotonergic and noradrenergic systems are preferentially affected at ZT1 and ZT13, respectively by milnacipran. We analyzed the plasma and brain levels of milnacipran after administration, and there were no differences between ZT1 and ZT13. The circadian rhythm of monoamine neurotransmitters was analyzed in several brain regions. The serotonin turnover showed rhythms with a peak during ZT18–ZT22 in hippocampus. The noradrenaline turnover showed rhythms with a peak during ZT22–ZT2. There was a difference of approx. 4 h between the serotonergic and noradrenergic systems. This time difference might be one of the factors that affect the action of milnacipran and contribute to the dosing time-dependent behavioral pattern in the FST. DOI： 10.1248/bpb.b17-00733 Short and long photoperiods differentially exacerbate corticosterone-induced physical and psychological symptoms in mice. Reviewed Hiroshi KAWAI, Jin INABE, Takuya ISHIBASHI, Naomi KUDO, Yoichi KAWASHI ... Biomedical Research   39 ( 1 )   47 - 55   2018.02 　More details Language：English   Publishing type：Research paper (scientific journal)   Publisher：Biomedical Research Press   DOI： 10.2220/biomedres.39.47 Disposition of perfluorododecanoic acid in male rats after an oral administration Reviewed Fundamental Toxicological Sciences   4 ( 4 )   179 - 186   2017.07 　More details Language：English   Publishing type：Research paper (scientific journal)   Publisher：日本毒性学会   DOI： 10.2131/fts.4.179 display all >> To the head of this page.▲ Books and Other Publications 【 display / non-display 】 To the head of this page.▲ Books and Other Publications 【 display / non-display 】 Pharmaceutical Health Science Satosi Asano, Sumiko Abe, Fuminori Ohtsuka, Yoichi Kawashima, Naomi Kudo, Akinori Sugiyama, Yasuhito Nakagawa, Atsushi Mitsumoto（ Role： Joint author ,  Part 5: Toxicology） Kyoto Hirokawa  2016.09  （ ISBN:9784906992881 ） 　More details Language：Japanese   Book type：Scholarly book Toxicological Effects of Perfluoroalkyl and Polyfluoroalkyl Substances Christopher Lau, Sonia Dagnino, Naomi Kudo, et al. （ Role： Joint author ,  Metabolism and Pharmacokinetics） Humana Press  2015  （ ISBN:978-3-319-15517-3 ） 　More details Language：English   Book type：Scholarly book Radiochemistry and Radioprmaceuticals Naomi Kudo（ Role： Joint author） Nankodo  2011.03  　More details Language：Japanese   Book type：Textbook, survey, introduction Pharmaceutical Sciences Masao Sato et al.（ Role： Joint author） Nankodo  2011.03  　More details Language：Japanese   Book type：Textbook, survey, introduction 環境・健康科学辞典(共著) 工藤なをみ（ Role： Joint author） 丸善　日本薬学会編  2005.01  　More details Language：Japanese   Book type：Dictionary, encyclopedia display all >> To the head of this page.▲ Misc 【 display / non-display 】 To the head of this page.▲ Misc 【 display / non-display 】 Study on bioaccumulation and safety estimation of fruorinated fatty acids Naomi Kudo Advances in Pharmaceutical Sciences   22   21 - 26   2006.03 　More details Authorship：Lead author   Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (other)   Publisher：The Research Foundation for Pharmaceutical Sciences   Toxicity and toxicokinetics of perfluorooctanoic acid in humans and animals. Kudo, N. and Kawashima, Y. J Toxicol Sci.   28 ( 2 )   49 - 57   2003.05 　More details Authorship：Lead author   Language：English   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)   不飽和脂肪酸の代謝とその調節機構 工藤なをみ、川嶋洋一 Radioisotopes   45   601 - 602   1996.06 　More details Authorship：Lead author   Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)   Publisher：日本アイソトープ協会   To the head of this page.▲ Presentations 【 display / non-display 】 To the head of this page.▲ Presentations 【 display / non-display 】 Tokicokinetics of PFAA International conference Naomi Kudo PFAA Mode of Action  United States of Environmental Protection Agency 　More details Event date： 2007.08 Language：English   Presentation type：Oral presentation (general)   Venue：Research Triangle Park, NC, USA   米国環境保護局の招待により、ペルフルオロアルキル化合物の安全性評価に関する最新の情報の発表と意見交換を行った。 Comparative toxicokinetics among PFAA and related chemistries International conference Naomi Kudo Perfluoroalkyl acids and related chemistries: Tokicokinetics and mode of action Workshop  Society of Toxicology, USA 　More details Event date： 2007.02 Language：English   Presentation type：Oral presentation (general)   Venue：Arlington, VA, USA   米国毒性学会の招待により、ペルフルオロアルキル化合物の体内動態に関する招待講演を行った。 To the head of this page.▲ Scientific Research Funds Acquisition Results 【 display / non-display 】 To the head of this page.▲ Scientific Research Funds Acquisition Results 【 display / non-display 】 ペルフルオロ化合物の生体残留性の検討と排泄促進剤の探索 2007.04 - 2010.03 科学研究費補助金  基盤研究(C) 　 More details ペルフルオロ化合物の生体残留性の検討と排泄促進剤の探索 フッ素系界面活性剤は代謝により活性化される 2006.04 - 2009.03 科学研究費補助金  基盤研究(C) 　 More details フッ素系界面活性剤は代謝により活性化される ペルフルオロアルキルテロマーアルコールの体内動態の解明とヒトにおける残存性の評価 2003.04 - 2006.03 科学研究費補助金  基盤研究(C) 　 More details ペルフルオロアルキルテロマーアルコールの体内動態の解明とヒトにおける残存性の評価 培養細胞系を用いた化学物質の吸収、排泄機構系の確立と安全性評価に関する研究 2000.04 - 2003.03 科学研究費補助金  基盤研究(C) 　 More details 培養細胞系を用いた化学物質の吸収、排泄機構系の確立と安全性評価に関する研究 フッ素化脂肪酸化合物を認識する新規細胞膜輸送体の検索とそのクローニング 1997.04 - 1999.03 科学研究費補助金  奨励研究(A) 　 More details フッ素化脂肪酸化合物を認識する新規細胞膜輸送隊の検索 display all >> To the head of this page.▲ Other External Funds 【 display / non-display 】 To the head of this page.▲ Other External Funds 【 display / non-display 】 フッ素系界面活性剤の生体内蓄積機構と安全性評価に関する研究 2002.04 - 2003.03 民間財団等  薬学研究奨励財団  　 More details Grant type：Competitive フッ素系界面活性剤の生体内蓄積機構と安全性評価に関する研究 難代謝性フッ素化脂肪酸の生体作用メカニズムの解明 1999.04 - 2000.03 民間財団等  武田科学振興財団  　 More details Grant type：Competitive 難代謝性フッ素化脂肪酸の生体作用メカニズムの解明 化学物質により誘発される脂肪肝の魚油摂取による改善の試み 1997.04 - 1998.03 民間財団等  医薬資源研究振興会  　 More details Grant type：Competitive 化学物質により誘発される脂肪肝の魚油摂取による改善の試み ペルフルオロカルボン酸の炭素鎖長の違いによる体内動態と肝特異性ペルオキシソーム増殖作用の解析 1996.04 - 1997.03 民間財団等  島原科学振興会研究助成金  　 More details Grant type：Competitive ペルフルオロカルボン酸の炭素鎖長の違いによる体内動態と肝特異性ペルオキシソーム増殖作用の解析 To the head of this page.▲ Past of Cooperative Research 【 display / non-display 】 To the head of this page.▲ Past of Cooperative Research 【 display / non-display 】 文部科学省科学研究補助金基盤研究(C) 2000.04 - 2003.03 民間企業  Collaboration in College  　 More details 文部科学省科学研究補助金基盤研究(C)薬物による不飽和脂肪酸合成制御の試みにおいて、研究代表者　川嶋洋一教授（本学）の研究分担者として研究に参画した。 文部省科学研究補助金基盤研究(C) 1997.04 - 2000.03 Collaboration in College  　 More details 文部省科学研究補助金基盤研究(C)ぺるふるおろ化合物の生体残留性の検討と再説促進剤の探索」において、研究代表者川嶋洋一　教授（本学）の分担研究者として研究を行った。 To the head of this page.▲   Committee Memberships 【 display / non-display 】 To the head of this page.▲ Committee Memberships 【 display / non-display 】 日本薬学会   代議員   2013.02    　 More details Committee type：Academic society 日本薬学会   薬学教育モデルコアカリキュラム改訂に関する調査研究チーム委員   2012.09 - 2013.09    　 More details Committee type：Academic society 日本薬学会   関東支部幹事   2008.02    　 More details Committee type：Academic society 日本薬学会   ファルマシア地区通信委員   2005.12    　 More details Committee type：Academic society 日本薬学会   ホームページ・薬学用語辞典小委員会委員   2005.04 - 2007.03    　 More details Committee type：Academic society display all >> To the head of this page.▲ Social Activities 【 display / non-display 】 To the head of this page.▲ Social Activities 【 display / non-display 】 厚生労働省薬事・食品衛生審議会臨時委員（動物用医薬品等部会） 厚生労働省薬事・食品衛生審議会  2017.01 厚生労働省薬事・食品衛生審議会専門委員（動物用医薬品残留問題調査会） 2015.09 　More details 動物用医薬品残留問題調査会 日本中央競馬会禁止薬物再検査制度立会人 2003.04 To the head of this page.▲   Copyright © Josai University, All Rights Reserved.