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Researchers Details of a Researcher Home Japanese このページはJavascriptを使用しています。すべての機能を使用するためにはJavascript を有効にする必要があります。 Personnel Information Profile Degree Research Areas From School From Graduate School Employment Record in Research External Career Professional Memberships Qualification Acquired Research Activity Research Career Papers Presentations Awards Scientific Research Funds Acquisition Results Contribution to Society Committee Memberships Social Activities Updated on 2024/04/26 Seki Tomohiro Affiliation Faculty of Pharmaceutical Sciences Department of Pharmaceutical Sciences Title Associate Professor Laboratory Address Josai University, bldg 21, room 423, Keyakidai 1-1, Sakado, Saitama, 350-0295, Japan Laboratory Phone number +81-49-271-8107 Laboratory Fax number 049-271-8107 Contact information External Link To the head of this page.▲ Degree 【 display / non-display 】 To the head of this page.▲ Degree 【 display / non-display 】 博士（薬学） ( 2016.03 城西大学 ) To the head of this page.▲ Research Areas 【 display / non-display 】 To the head of this page.▲ Research Areas 【 display / non-display 】 Life Science / Pharmaceutical analytical chemistry and physicochemistry To the head of this page.▲ From School 【 display / non-display 】 To the head of this page.▲ From School 【 display / non-display 】 Josai University Faculty of Pharmaceutical Science Graduated 2006.04 - 2012.03 More details Country：Japan To the head of this page.▲ From Graduate School 【 display / non-display 】 To the head of this page.▲ From Graduate School 【 display / non-display 】 Josai University Graduate School, Division of Pharmaceutical Sciences Doctor&＃39;s Course Completed 2012.04 - 2016.03 More details Country：Japan To the head of this page.▲ Employment Record in Research 【 display / non-display 】 To the head of this page.▲ Employment Record in Research 【 display / non-display 】 Josai University Faculty of Pharmaceutical Sciences Department of Pharmaceutical Sciences Associate Professor 2024.04 Josai University Faculty of Pharmaceutical Sciences Department of Pharmaceutical Sciences Assistant Professor 2019.04 - 2024.03 To the head of this page.▲ External Career 【 display / non-display 】 To the head of this page.▲ External Career 【 display / non-display 】 National Institutes of Health Ntional Cancer Institute, Center for Cancer Research, Radiation Biology Branch Researcher 2016.07 - 2018.01 More details Country：United States National Institutes of Health Ntional Cancer Institute, Center for Cancer Research, Radiation Biology Branch 2018.02 - 2019.03 More details Country：United States To the head of this page.▲ Professional Memberships 【 display / non-display 】 To the head of this page.▲ Professional Memberships 【 display / non-display 】 日本薬剤学会 2012.03 日本薬学会 2011.03 日本DDS学会 2011.03 日本シクロデキストリン学会 2011.03 - 2016.03 To the head of this page.▲ Qualification Acquired 【 display / non-display 】 To the head of this page.▲ Qualification Acquired 【 display / non-display 】 Pharmacist To the head of this page.▲ Research Career 【 display / non-display 】 To the head of this page.▲ Research Career 【 display / non-display 】 高分子ナノシートを用いたin vitro薬物膜透過評価への適用と経皮薬物送達システムへの応用 (not selected) Project Year： 2019.04 - CD44陽性がん標的指向性を有するプロドラッグ型グルタチオン応答薬物放出システム Grant-in-Aid for Scientific Research Project Year： 2019.04 - インスリン製剤のアミロイド化に関する基礎的研究 (not selected) Project Year： 2019.04 - 動的核偏極MRIを用いた非侵襲的in vivo腫瘍代謝イメージング (not selected) Project Year： 2016.07 - 糖応答性インスリン放出システムに関する (not selected) Project Year： 2010.04 - To the head of this page.▲ Papers 【 display / non-display 】 To the head of this page.▲ Papers 【 display / non-display 】 Sugar-sensitive supramolecular structures based on phenylboronic acid-modified cyclodextrins Reviewed International journal Kiminobu Nakamura, Tomohiro Seki, Yuya Egawa, Ryotaro Miki, Yoshiki Oda, Takashi Yamanoi, Toshinobu Seki Chemical and Pharmaceutical Bulletin 61 ( 11 ) 1188 - 1191 2013 More details Language：English Publishing type：Research paper (scientific journal) Publisher：J-Stage Supramolecular structures were developed from phenylboronic acid-modified cyclodextrins (PBA-CyDs). The intermolecular interaction between the PBA moiety and the CyD cavity was proved using 2D NMR and powder X-ray diffraction techniques. PBA-α-CyD formed a head-to-tail supramolecular polymer, whereas PBA-β-CyD formed a head-to-head dimer. The supramolecular structures were disintegrated in the presence of sugars owing to the resulting boronate sugar interactions. Sugar-responsive pseudopolyrotaxanes and their application in sugar-induced release of PEGylated insulin Reviewed Tomohiro Seki, Keigo Abe, Kiminobu Nakamura, Yuya Egawa, Ryotaro Miki, Kazuhiko Juni, Toshinobu Seki Journal of Inclusion Phenomena and Macrocyclic Chemistry 82 ( 3-4 ) 417 - 424 2015 More details Authorship：Lead author Language：English Publishing type：Research paper (scientific journal) Sugar-Responsive Pseudopolyrotaxane Composed of Phenylboronic Acid-Modified Polyethylene Glycol and γ-Cyclodextrin Reviewed Tomohiro Seki, Misato Namiki, Yuya Egawa, Ryotaro Miki, Kazuhiko Juni and Toshinobu Seki Materials 8 ( 3 ) 1341 - 1349 2015 More details Authorship：Lead author Language：English Publishing type：Research paper (scientific journal) We have designed a sugar-responsive pseudopolyrotaxane (PPRX) by combining phenylboronic acid-modified polyethylene glycol (PBA-PEG) and γ-cyclodextrin. Phenylboronic acid (PBA) was used as a sugar-recognition motif in the PPRX because PBA reacts with a diol portion of the sugar molecule and forms a cyclic ester. When D-fructose or D-glucose was added to a suspension of PPRX, PPRX disintegrated, depending on the concentration of the sugars. Interestingly, catechol does not show a response although catechol has a high affinity for PBA. We analyzed the response mechanism of PPRX by considering equilibria. A Pseudopolyrotaxane for Glucose-Responsive Insulin Release: The Effect of Binding Ability and Spatial Arrangement of Phenylboronic Acid Group Reviewed Tomohiro Seki, Keigo Abe, Yuya Egawa, Ryotaro Miki, Kazuhiko Juni, and Toshinobu Seki Molecular Pharmaceutics 13 ( 11 ) 3807 - 3815 2016 More details Authorship：Lead author Language：English Publishing type：Research paper (scientific journal) A pseudopolyrotaxane (PPRX) comprising 3-carboxy-5-nitrophenylboronic acid modified γ-cyclodextrin (NPBA-γ-CyD) and naphthalene modified polyethylene glycol (Naph-PEG) as a sugar-responsive supramolecular structure is prepared. The binding of sugar by the NPBA group induced disintegration of the Naph-PEG/NPBA-γ-CyD PPRX, allowing the components to be dissolved. The Naph-PEG/NPBA-γ-CyD PPRX exhibited better sensitivity compared to that of a PPRX based on 4-carboxyphenylboronic acid modified γ-cyclodextrin (PBA-γ-CyD). We have previously reported the unique structure of Naph-PEG/PBA-γ-CyD PPRX, which formed an inclusion complex with a single-stranded PEG chain being threaded through the γ-CyD rings, with the remaining internal space being occupied by the sugar-sensing PBA moiety from a neighboring ring, thus shielding it from sugar molecules and reducing the sugar sensitivity of the PPRX. In contrast, structural analyses in this study revealed that the sugar-sensing NPBA moiety in the Naph-PEG/NPBA-γ-CyD PPRX is not included in the neighboring NPBA-γ-CyD. This spatial arrangement and the high affinity of NPBA for sugar contributed to the improved sugar responsivity. The enhanced NPBA-γ-CyD was then applied to a PPRX containing Naph-PEG-appended insulin (Naph-PEG-Ins) that showed an improved response for glucose-induced insulin release. A polyrotaxane gel using boronic acid-appended γ-cyclodextrin as a hybrid cross-linker Reviewed Wataru Uchida, Maiki Yoshikawa, Tomohiro Seki, Ryotaro Miki, Toshinobu Seki, Takashi Fujihara, Yoshihiro Ishimaru, Yuya Egawa Journal of Inclusion Phenomena and Macrocyclic Chemistry 89 ( 3-4 ) 281 - 288 2017 More details Language：English Publishing type：Research paper (scientific journal) A boronic acid-appended γ-cyclodextrin (BA-CyD) was synthesized as a hybrid cross-linker of polyvinyl alcohol (PVA) to form a new type of hydrogel. The CyD moiety of BA-CyD forms an inclusion complex with the PVA chain to produce a mechanically interlocking structure. At the same time, the BA moiety of BA-CyD forms covalent bonds with the 1,3-diol moieties of PVA. On the basis of these two modes of interaction, the hybrid cross-linker connects two PVA chains, thus resulting in the formation of a hydrogel. To investigate the possibility of this hydrogel becoming the basis for an intelligent material for drug delivery, sugar-responsive drug release from the hydrogel was demonstrated. display all >> To the head of this page.▲ Presentations 【 display / non-display 】 To the head of this page.▲ Presentations 【 display / non-display 】 フェニルボロン酸修飾シクロデキストリンを用い糖応答性分子ネックレスの調製 関 智宏, 江川 祐哉, 中村 公薫, 関 俊暢 日本薬学会第131年会 More details Event date： 2011.03 フェニルボロン酸修飾シクロデキストリンを用いた糖応答性ポリシュードロタキサンの調製 関 智宏, 江川 祐哉, 中村 公薫, 関 俊暢 第27回日本Drug Delivery System学会学術集会 More details Event date： 2011.06 フェニルボロン酸修飾シクロデキストリンを用いた糖存在下で崩壊するポリシュードロタキサンの調製 関 智宏, 江川 祐哉, 中村 公薫, 関 俊暢 第28回シクロデキストリンシンポジム More details Event date： 2011.09 フェニルボロン酸修飾シクロデキストリンとポリエチレングリコールにより形成される糖応答性超分子ネックレスの構造解析 関 智宏, 江川 祐哉, 中村 公薫, 関 俊暢 日本薬学会第132年会 More details Event date： 2012.03 血糖値応答性インスリンデリバリー基剤としてのシクロデキストリン誘導体超分子 関 智宏, 江川 祐哉, 中村 公薫, 小田 慶喜, 山ノ井 孝, 関 俊暢 日本薬剤学会第27年会 More details Event date： 2012.05 display all >> To the head of this page.▲ Awards 【 display / non-display 】 To the head of this page.▲ Awards 【 display / non-display 】 最優秀発表者賞 2011.08 城西大学 関 智宏 More details Country：Japan ポスター賞 2013.09 第30回シクロデキストリンシンポジウム (日本シクロデキストリン学会) 関 智宏 More details Award type：Award from Japanese society, conference, symposium, etc. Country：Japan 優秀発表賞 2014.03 日本薬学会 第134年会 関 智宏 More details Award type：Award from Japanese society, conference, symposium, etc. Country：Japan Most Impressive Debater賞 2014.05 日本薬剤学会第29年会 関 智宏 More details Award type：Award from Japanese society, conference, symposium, etc. Country：Japan 若手研究奨励賞 2014.07 物理系薬学部会 (フィジカルファーマフォーラム2014) 関 智宏 More details Award type：Award from Japanese society, conference, symposium, etc. Country：Japan display all >> To the head of this page.▲ Scientific Research Funds Acquisition Results 【 display / non-display 】 To the head of this page.▲ Scientific Research Funds Acquisition Results 【 display / non-display 】 CD44陽性がん標的指向性を有するプロドラッグ型グルタチオン応答薬物放出システム Grant number：20K16421 2020.04 - 2023.03 科学研究費補助金 若手研究 More details Authorship：Principal investigator CD44がん標的能とエンドソーム脱出能を持つグルタチオン応答プロドラッグ型DDS Grant number：23K14660 2023.04 - 2026.03 科学研究費補助金 若手研究 More details Authorship：Principal investigator To the head of this page.▲ Committee Memberships 【 display / non-display 】 To the head of this page.▲ Committee Memberships 【 display / non-display 】 日本薬剤学会 第30回日本薬剤学会学生主催シンポジウムSNPEE2015 委員 2015.05 - 2016.05 More details Committee type：Academic society To the head of this page.▲ Social Activities 【 display / non-display 】 To the head of this page.▲ Social Activities 【 display / non-display 】 埼玉県立岩槻高校 模擬授業 「からだの中での薬の運命」 Role(s)： Lecturer 埼玉県立岩槻高校 2020.11 More details Audience： High school students 叡明高校 模擬授業 「からだの中での薬の運命」 Role(s)： Lecturer 2021.12 埼玉県立小川高校 模擬授業 「からだの中での薬の運命」 Role(s)： Lecturer 2023.11 More details Type：Visiting lecture To the head of this page.▲ Copyright © Josai University, All Rights Reserved.
